The Neroverdi took the lead in the eighth minute through centre-back Francesco Acerbi. Vincenzo Montella’s side had no response and they went 2-0 down in the 26th minute as Sergio Floccari scored his third of the season. Lorenzo Pellegrini added a final blow in the 38th minute. Ervin Zukanovic added a consolation for Sampdoria in the 89th minute.
It was the away side who started in a hurry, and in the eighth minute the Neroverdi opened the scoring. Sassuolo played a short corner which led to Matteo Politano whipping in an in-swinging cross. Defender Acerbi was quickest to react and he stuck out a leg, diverting the ball past a stranded Emiliano Viviano.
Il Doria looked shot of confidence, whereas the Neroverdi were in cruise control and they doubled their lead in the 26th minute. Sime Vrsjalko darted down the right flank before firing in a low cross which reached Floccari, who calmly dispatched his effort into the net.
Floccari almost scored his second 10 minutes later. Federico Peluso slipped in the Italian but he was denied by a stunning Viviano save.
Sampdoria were clueless defensively as the Neroverdi further asserted their dominance. A slick one two between Pellegrini and Politano put through Pellegrini whose first effort was saved, but he made no mistake with the rebound, as he fired past Viviano.
Sampdoria almost reduced the arrears moments later. Antonio Cassano threaded a pass to Eder but he fired wide. The half ended 3-0.
The second-half continued in similar fashion as Politano almost added a fourth. Following an inspired run, his shot cannoned off a defender and looped just over the bar.
The Blucerchiati did wrestle control of the match back from Sassuolo, but chances were few and far between as the Neroverdi shut up shop.
Il Doria did get a consolation goal late on. A cross was flung in and Ervin Zukanovic came in at the back post to head in.
The result leaves Sampdoria in 14th place, with just one win in their last 10 matches.