Olympiacos and AC Milan face off in Piraeus knowing that only one of them can progress to the Europa League knockout phase alongside Group F table toppers Real Betis.
Milan sit three points ahead of the Greek side, who will leapfrog the Rossoneri into second place on the head-to-head rule if they beat them 2-0, 3-1 or by a margin of three goals or more.
Thankfully for Milan, Olympiacos have just three victories in 12 matches at home against Italian opposition. However, Milan have never won in Greece.
Olympiacos: Jose Sà; Elabdellaoui, Vukovic, Cisse, Koutris; Camara, Guilherme; Fetfatzidis, Fortounis, Podence; Guerrero
AC Milan: Reina; Calabria, Abate, Zapata, Rodriguez; Castillejo, Kessie, Bakayoko, Calhanoglu; Cutrone, Higuain