After moving above them in the table in midweek, Roma look to extend the gap over rivals Napoli in the Derby del Sole in Serie A on Saturday.
The Giallorossi easily swatted aside Udinese 4-0 on Wednesday, despite playing for over an hour with 10 men, and the victory lifted them to fourth.
Meanwhile, Napoli’s controversial 2-2 draw against Atalanta earlier in the evening allowed Roma to leapfrog them.
The most recent meeting between the pair saw Napoli run out 4-1 winners in March, with Roma only winning one of the past five encounters.
Former Giallorossi centre-back Kostas Manolas makes his first return to the Stadio Olimpico since joining Napoli in the summer, whilst Edin Dzeko once again leads the line for Roma.
Roma: Pau Lopez; Spinazzola, Cetin, Smalling, Kolarov; Mancini, Veretout; Zaniolo, Pastore, Kluivert; Dzeko
Napoli: Meret; Lorenzo, Manolas, Koulibaly, Mario Rui; Callejon, Fabian Ruiz, Zielinski, Insigne; Milik, Mertens