The Stadio Via del Mare hosts the return of Serie A football for visitors AC Milan, who will be hoping for a better result against hosts Lecce from their reverse fixture.
Lecce are the only side Milan have defeated in Serie A having trailed initially by three goals; the 4-3 result coming in 2011 courtesy of Kevin-Prince Boateng and Mario Yepes.
With 56 goals conceded already this season the Giallorossi will be counting on the Milan attack prolonging their sluggish return to competitive action.
Lecce: Gabriel; Rispoli, Lucioni, Meccariello, Calderoni; Petriccione, Tachtsidis, Mancosu; Falco, Saponara; Lapadula
Milan: Donnarumma; Conti, Kjaer, Romagnoli, Theo Hernandez; Castillejo, Kessie, Bennacer, Bonaventura; Calhanoglu; Rebic