A run of five victories in six games has lifted Claudio Ranieri’s side to safety, but the Grifone remain at risk of being dragged into a relegation battle as they are just four points ahead of 18th-placed Lecce.
In December, the game was decided by a Manolo Gabbiadini strike with five minutes left on the clock.
The Rossoblu have some unflattering history to conquer, as they have failed to beat their rivals in the last seven derbies, drawing two and losing five, which is the longest winless run in this fixture since 1994.
Sampdoria: Audero; Bereszynski, Yoshida, Colley, Augello; Linetty, Ekdal, Thorsby, Jankto; Bonazzoli, Gabbiadini
Genoa: Perin; Biraschi, Romero, Masiello, Criscito; IagoFalque, Lerager, Schone, Jagiello; Pinamonti, Pandev