The Aquile are on a wretched run that has seen their Scudetto challenge collapse, but have history on their side in Friuli, having won their last seven league meetings with Udinese.
However, defeat would see Lazio endure their longest losing streak since 2009, after failing to pick up a point in their most recent Serie A matches.
Udinese themselves are in something of a rut, with just two victories in their last 13 matches. Only bottom club Brescia have won fewer matches in that period, although the Zebrette did secure a win over Roma in that period.
Lazio; Strakosha; Luiz Felipe, Acerbi, Radu; Lazzari, Milinkovic-Savic, Parolo, Luis Alberto, Jony; Caicedo, Immobile