The 27-year-old battled with injuries during the 2019/20 campaign, featuring just nine times in Serie A, but this has not detracted any interest from abroad.
Sevilla have Monchi as their director of football and he has had experience in Italy with Roma so he is already familiar with the 27-year-old. The Andalucian club have also qualified for the Champions League, potentially luring the defender that way.
Villarreal have qualified for the Europa League and they have already made several signings, with De Sciglio being a potential reinforcement for the defence.
Valencia have not qualified for Europe but they have acquired Italian full-backs in the past. Roma defender Alessandro Florenzi recently spent a loan spell at the club while Cristiano Piccini has been with Los Che since 2018.