The meeting will be the first between the two sides, but the Rossoneri will be hoping for a more favourable result than they achieved in their last visit to Ireland.
Rovers’ form might give Milan slight cause for concern though, with the Hoops topping the League of Ireland, boasting an eight-point lead as they are still unbeaten in their 11 games so far.
The Irish side do have previous against Italian opposition as they faced Juventus in the Europa League’s third qualification round in 2010/11.
Shamrock Rovers: Mannus; O’Brien, Lopes, Grace; Finn, McEneff, O’Neill, J Byrne, Farrugia; Burke, Greene
AC Milan: G. Donnarumma; Calabria, Kjaer, Gabbia; Theo Hernandez; Kessie, Bennacer; Castillejo, Calhanoglu, Saelemaekers; Ibrahimovic