This will be a special match for Rossoneri coach Stefano Pioli, who will be facing his hometown club as well as a former team that he played for and coached.
Milan will be without Danish centre-back Simon Kjaer and Swedish striker Zlatan Ibrahimovic, who are still recovering from muscular injuries.
Meanwhile, the Ducali are missing right-back Vincent Laurini with a muscle injury, midfielder Alberto Grassi has an injured shoulder, and veteran midfielder Juraj Kucka is recovering from bruising.
AC Milan: Donnarumma; Calabria, Gabbia, Romagnoli, Hernandez; Kessie, Bennacer; Castillejo, Calhanoglu, Diaz; Rebic
Parma: Sepe; Iacoponi, Osorio, Alves, Gagliolo; Hernani, Brugman, Kurtic; Karamoh, Cornelius, Gervinho.