Despite their struggles on the continent, the Nerazzurri have found some form domestically and seek a fourth consecutive victory. Meanwhile, clashes against their Sardinian opponents have proved fruitful for Inter in recent years, with five wins in the last seven meetings.
Cagliari are looking for just a second win in six Serie A matches, with their last league success coming over a month ago in a 2-0 victory over Sampdoria.
Cagliari: Cragno; Farago, Walukiewicz, Carboni, Lykogiannis; Marin, Rog; Zappa, Joao Pedro, Sottil; Pavoletti
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Perisic; Eriksen; Sanchez, Lukaku