Atalanta raced into an early lead as Robin Gosens put them ahead after just three minutes, tucking home at the back post from a Ruslan Malinovskyi cross. Davide Zappacosta extended the advantage further late in the first half, after a wonderful team move allowed Duvan Zapata to release him for a low finish.
However, Sassuolo halved the deficit on the stroke of half time through Domenico Berardi, as the Italian international cut in from the right and drilled in a powerful low effort from range.
La Dea were comfortable after the break and limited the visitors to few clear chances, with Giacomo Raspadori seeing a rare opportunity at goal. Atalanta were well worth their victory, and move into fourth place.